ALTERNATIVE POTENCY TESTS FOR QUALITY CONTROL OF IMMUNOBIOLOGICALS: A CRITICAL REVIEW OF THE VALIDATION APPROACH

Alternative potency tests for quality control of immunobiologicals: a critical review of the validation approach

Introduction: In addition to low reproducibility, in vivo potency tests used in the quality control of immunobiological products require too many animals, causing them significant pain and suffering.In the last decades, many studies have been conducted to validate alternative methods for quality control and Feeding frequency affects feed intake and

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Azacitidine and lenalidomide combination: a novel relapse prophylaxis regimen after allogeneic hematopoietic stem-cell transplantation in patients with acute myeloid leukemia

IntroductionWhile allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a curative regimen for acute myeloid leukemia (AML), relapse of AML remains a serious risk post-transplantation.Once relapsed, salvage options are limited and management of AML is difficult.Here we designed a prospective study to examine the efficacy and tolerab

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Direct patient costs of maternal care and birth-related complications at faith-based hospitals in Madagascar: a secondary analysis of programme data using patient invoices

Objectives We aimed to determine the rate of catastrophic health expenditure incurred by women using maternal healthcare services at faith-based hospitals in Madagascar.Design This was a secondary analysis of programmatic data obtained from a non-governmental organisation.Setting Two faith-based, secondary-level hospitals located in rural communiti

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Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial

Abstract Metabolic syndrome (MeS) is a common multifaceted disorder.Plants contain antioxidant bioactive compounds, which are beneficial to improve the health condition of patients with MeS.Propolis is a hive natural product that is composed of various constituent.We aimed to assess the effects of Iranian propolis as a natural and safe agent on ind

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